Andrea:<br>I believe you should simply make a script for consecutive runs. <br><br>Andrea Bortolato wrote:<br><div class="gmail_quote"><blockquote class="gmail_quote" style="border-left: 1px solid rgb(204, 204, 204); margin: 0pt 0pt 0pt 0.8ex; padding-left: 1ex;">
> Dear all,<br>
><br>
> I would like to increase linearly the force constant of some distance constraints during my MD and then decrease it:<br>
><br>
> 2 ps for 100 cycles with the force constant being raised by 50 kj mol^(-1) nm^(-2)<br>
><br>
> 2 ps for 100 cycles with the force constant being reduced by 50 kj mol^(-1) nm^(-2)<br>
><br>
> is there a way to do it with gromacs? I looked carefully in the manual and in the mailing list too, but I couldn't find an option to do this<br>
</blockquote></div><br>