<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Dear GMX users,</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> I am facing problem while
doing energy minimization before the molecular dynamic simulation step of a system
consisting of protein, membrane, water and 14 ions. </span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">The minim.mdp file is as follows</span></p>


<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">-------------------------------------------------------------------------------------------------------------</span></p>


<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">; minim.mdp - used as input into
grompp to generate em.tpr</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">; Parameters describing what to
do, when to stop and what to save</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">integrator<span>         </span>= steep<span>             </span>;
Algorithm (steep = steepest descent minimization)</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">emtol<span>               </span>= 1000.0<span>  </span><span>        </span>; Stop minimization when the maximum
force &lt; 1000.0 kJ/mol/nm</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">emstep<span>      </span>= 0.01<span>      </span>; Energy step size</span></p>


<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">nsteps<span>              </span>= 50000<span>           </span><span>  </span><span>          </span>;
Maximum number of (minimization) steps to perform</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> </span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">; Parameters describing how to
find the neighbors of each atom and how to calculate the interactions</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">nstlist<span>               </span>= 1<span>                   </span><span>  </span>; Frequency to update the neighbor list and
long range forces</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">ns_type<span>                        </span>= grid<span>  </span>;
Method to determine neighbor list (simple, grid)</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">rlist<span>                  </span>= 1.2<span>                </span><span>    </span>; Cut-off for making neighbor list (short
range forces)</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">coulombtype<span>   </span>= PME<span>             </span>;
Treatment of long range electrostatic interactions</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">rcoulomb<span>         </span>= 1.2<span>                </span>;
Short-range electrostatic cut-off</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">rvdw<span>                </span>= 1.2<span>                </span>;
Short-range Van der Waals cut-off</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">pbc<span>                  </span>= xyz <span>              </span>; Periodic Boundary Conditions</span><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> </span></p>


<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><b><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">---------------------------------------------------------------------------------------------------------</span></b></p>


<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">when I run this using the command </span></p>


<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><b><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> </span></b></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><b><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">grompp –f minim_1.mdp –c system_inflated.gro
topol.top –o em.tpr </span></b><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"></span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> </span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> then I invoked mdrun which
gave following error</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">--------------------------------------------------------------------------------------------------------</span></p>


<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Reading file topol.tpr, VERSION 4.0.7 (single
precision)</span></p>

<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Loaded with Money</span></p>

<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> </span></p>

<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Steepest Descents:</span></p>

<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><span>   </span>Tolerance
(Fmax)<span>   </span>=<span>  </span>1.00000e+03</span></p>

<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><span>   </span>Number of
steps<span>    </span>=<span>        </span>50000</span></p>

<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Step=<span>   </span>14,
Dmax= 1.2e-06 nm, Epot=<span>  </span>3.03531e+22
Fmax=<span>         </span>inf, atom= 1417</span></p>

<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Stepsize too small, or no change in energy.</span></p>

<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Converged to machine precision,</span></p>

<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">but not to the requested precision Fmax &lt; 1000</span></p>

<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> </span></p>

<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Double precision normally gives you higher accuracy.</span></p>

<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">You might need to increase your constraint accuracy,
or turn</span></p>

<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">off constraints alltogether (set constraints = none
in mdp file)</span></p>

<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> </span></p>

<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">writing lowest energy coordinates.</span></p>

<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> </span></p>

<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Steepest Descents converged to machine precision in
15 steps,</span></p>

<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">but did not reach the requested Fmax &lt; 1000.</span></p>

<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Potential Energy<span> 
</span>=<span>  </span>3.0353124e+22</span></p>

<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Maximum force<span>    
</span>=<span>            </span>inf on atom 1417</span></p>

<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Norm of force<span>    
</span>=<span>            </span>inf</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">-----------------------------------------------------------------</span></p>


<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">After this I changed the </span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">emstep<span>      </span>= 0.1<span>     
</span>; Energy step size</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">nsteps<span>          </span>= 5000<span>  </span>; Maximum number of (minimization) steps to
perform</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">constraints<span>     </span>= none</span></p>


<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">After these changes the no of steps
increased to 18 but still the system did not converge and potential energy is
very high</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">----------------------------------------------------------------------------------------------------------</span></p>


<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> </span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Reading file em.tpr, VERSION 4.0.7
(single precision)</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Loaded with Money</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> </span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Steepest Descents:</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><span>  
</span>Tolerance (Fmax)<span>   </span>=<span>  </span>1.00000e+03</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><span>  
</span>Number of steps<span>    </span>=<span>         </span>5000</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Step=<span>   </span>17, Dmax= 1.5e-06 nm, Epot=<span>  </span>3.03531e+22 Fmax=<span>         </span>inf, atom= 1417</span></p>



<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Stepsize too small, or no change in
energy.</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Converged to machine precision,</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">but not to the requested precision
Fmax &lt; 1000</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> </span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Double precision normally gives you
higher accuracy.</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">You might need to increase your
constraint accuracy, or turn</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">off constraints alltogether (set
constraints = none in mdp file)</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> </span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">writing lowest energy coordinates.</span></p>


<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> </span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Steepest Descents converged to
machine precision in 18 steps,</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">but did not reach the requested Fmax
&lt; 1000.</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Potential Energy<span>  </span>=<span> 
</span>3.0353124e+22</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Maximum force<span>     </span>=<span>            </span>inf on atom 1417</span></p>


<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Norm of force<span>     </span>=<span>            </span>inf</span></p>


<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">----------------------------------------------------------------------------------------------------------------</span></p>


<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">What changes can I do in my minim.mdp
file to converge my system and get a negative value of Epot.</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> </span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">The topol.top file looks </span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">--------------------------------------------------------------------------------------------------</span></p>


<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">[ system ]</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">; Name</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">protein</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">128-Lipid DPPC Bilayer </span></p>


<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> </span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">[ molecules ]</span></p>


<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">; Compound<span>        </span>#mols</span></p>


<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Protein_A<span>           </span>1</span></p>


<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">DPPC<span>                </span>121</span></p>


<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> </span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">SOL<span>             </span>11107</span></p>


<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal;text-autospace:none"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">CL- <span>                             </span>14</span></p>


<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">-----------------------------------------------------------------------------------------------------</span></p>


<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Thanks,</span></p>

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;line-height:normal"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Parul </span></p>

<p class="MsoNormal"><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> </span></p>