<html><head><style type="text/css"><!-- DIV {margin:0px;} --></style></head><body><div style="font-family:'times new roman', 'new york', times, serif;font-size:12pt"><div>Hi,</div><div> Occasionally I hear that one need to use WHAM( weighed histogram analysis) method in collaboration with Temperature-Replica exchange simulation. But, I was not understanding why one need to use WHAM with temperature-remd simulation. Can someone explain me ?</div><div>Does one need to use any sorts of WHAM to analyze the trajectory obtained from T-REMD simulation of Gromacs ?</div><div> The fact is that I am trying some replica-exchange simulation in gromacs and I get all the trajectory which I believed corresponds to each individual temperature. I was wondering whether someone can explain me whether I need to some WHAM-like post processing to get the data.</div><div>Sanku</div><div style="position:fixed"></div>
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