<table cellspacing="0" cellpadding="0" border="0" ><tr><td valign="top" style="font: inherit;"><DIV>To whom it may concern;</DIV>
<DIV>I am willing to study a damaged DNA which has a 8-oxoG as the lesion (the Carbon 8 in guannine is oxidized.). I have the following questions;</DIV>
<DIV>1) Should I change the sigma and epsilon parameters in the force field that I want to work on? and how?</DIV>
<DIV>2) Should I change the bonded parameters in the force field? and how?</DIV>
<DIV>3) The new charges for the lesion are obtained from Gaussian package; where can I mention the modified charges?</DIV>
<DIV> </DIV>
<DIV>Thank you for your regards</DIV>
<DIV>B.Mehrazma</DIV></td></tr></table>