<table cellspacing="0" cellpadding="0" border="0" ><tr><td valign="top" style="font: inherit;"><BR><BR>--- On <B>Sat, 12/24/11, banafsheh mehrazma <I><bmehrazma@yahoo.com></I></B> wrote:<BR>
<BLOCKQUOTE style="PADDING-LEFT: 5px; MARGIN-LEFT: 5px; BORDER-LEFT: rgb(16,16,255) 2px solid"><BR>From: banafsheh mehrazma <bmehrazma@yahoo.com><BR>Subject: <BR>To: gmx-users@gromacs.org<BR>Date: Saturday, December 24, 2011, 3:39 AM<BR><BR>
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<DIV>To whom it may concern;</DIV>
<DIV>I am willing to study a damaged DNA which has a 8-oxoG as the lesion (the Carbon 8 in guannine is oxidized.). I have the following questions;</DIV>
<DIV>1) Should I change the sigma and epsilon parameters in the force field that I want to work on? and how?</DIV>
<DIV>2) Should I change the bonded parameters in the force field? and how?</DIV>
<DIV>3) The new charges for the lesion are obtained from Gaussian package; where can I mention the modified charges?</DIV>
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<DIV>Thank you for your regards</DIV>
<DIV>B.Mehrazma</DIV></TD></TR></TBODY></TABLE></DIV></BLOCKQUOTE></td></tr></table>