<html><body><div style="color:#000; background-color:#fff; font-family:times new roman, new york, times, serif;font-size:12pt"><div>Dear all</div><div> </div><div>I run a MD on a GPCR (transmembrane protein)</div><div>Then I run a PCA on results and I found 3PC sufficient to explain variance.</div><div>On the same PC I get big values for samples located both at Nter (extracellular) and Cter (intracellular) or for similar cases such as both Nter(extracellular) and Loop5 (intracellular).According to you how could I explain the motion of group atoms intra and extracellular on the same components? </div><div>Does it mean the motion of some atoms at Nter (for instance) could influence the motion at Cter ? Could it be logic?</div></div></body></html>