<h1 style="margin-top:5.55pt;margin-right:0cm;margin-bottom:5.55pt;margin-left:0cm;text-align:justify;text-justify:inter-ideograph;background:white"><span lang="EN-US" style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;;color:#444444;font-weight:normal">Dear Gromacs developer:</span></h1>


<p class="MsoNormal" style="margin-left:0cm;background:white"><span lang="EN-US" style="font-size:10.0pt;font-family:Symbol;color:#4f6b72">·<span style="font:7.0pt &quot;Times New Roman&quot;">                                
</span></span><span lang="EN-US" style="font-size:12.0pt">I
would like to simulate a reaction with 50 explicit water molecules with QM/MM
(orca/gmx), and then add a implicit solvent model around this cluster (reaction
center + 50 waters). But when I search the gromacs mailing list and gromacs
manual, I get this “<span style="color:blue">With the release of GROMACS
version 4.5, it is possible to conduct simulations using implicit solvent
models;…….</span>”  I was wondering is
there any possibility to perform QM/MM calculation (orca/gmx) along with implicit solvent
model?</span><span lang="EN-US" style="font-size:12.0pt;color:#4f6b72"></span></p>

<span lang="EN-US" style>Thanks in advance. </span>